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A complete cure is possible, but remember that a pilonidal cyst may recur even if you had one surgically removed. WebMD Medical Reference Reviewed by Stephanie S. Gardner, MD on March 06, 2019 Sources (Redirected from Pilonidal cyst). Pilonidal disease is a type of skin infection which typically occurs as a cyst between the cheeks of the buttocks and often at the upper end. Symptoms may include pain, swelling, and redness. There may also be drainage of fluid, but rarely a fever.